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Vol. 34 No. 4 (2022): Vol 34 Issue 4, 2022

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In vitro Assessment of Antioxidant and Anticancer Potential of Flavonoid Glycosides of Glinus oppositifolius (L.) Aug. DC.

https://doi.org/10.14233/ajchem.2022.23664
K. Suresh Kannan
Department of Botany, Thanthai Periyar Government Arts and Science College (Autonomous) (Affiliated to Bharathidasan University), Tiruchirappalli-620023, India
D. Kandavel
Department of Botany, Thanthai Periyar Government Arts and Science College (Autonomous) (Affiliated to Bharathidasan University), Tiruchirappalli-620023, India
P. Rajalakshmi
Department of Zoology, Queen Mary’s College, Chennai-600004, India

Corresponding Author(s) : D. Kandavel

kandavel1976@gmail.com

Asian Journal of Chemistry, Vol. 34 No. 4 (2022): Vol 34 Issue 4, 2022

Abstract

Development of unbalanced state of free radicals and their elimination in the body is the reason for increase in different types of chronic diseases including cancer. A better natural supplement to play role of antioxidants to combat the free radicals and to reduce the risk of cancer is in high demand. This current research work focused on identifying such a potent phytocompounds from Glinus oppositifolius (L.) Aug. DC. The active compounds of the aerial parts of the plant have been extracted using methanol and the phytochemical analysis was carried out using qualitative tests, FTIR and GC-MS. The plant extract found to contain range of phyto compounds with good amounts of flavonoid and xylofuranoside. Flavonoid glycoside from the plant extract has been partially purified through chromatography and tested for efficiency against free radicals through in vitro antioxidant assays. The partially purified compound showed good antioxidant activity equivalent to 62.12 to 63.35 μg of rutin standard. Further cytotoxic nature of the flavonoid glycoside was also assessed against breast cancer MDA-MB-231 cell line. The tested compound has shown cancerous cell controlling ability (76.68% cell death in 24 h). The immense antioxidant and anticancer potential of flavonoid glycosides of G. oppositifolius could be utilized as a good source of natural, antioxidant supplement under nutraceuticals to prevent oxidative-stress-related disorders and also as therapeutic compound to cure cancer under pharmaceuticals.

Keywords

Glinus oppositifolius Flavonoid glycosides Antioxidant activity Anticancer activity
Suresh Kannan, K., Kandavel, D., & Rajalakshmi, P. (2022). In vitro Assessment of Antioxidant and Anticancer Potential of Flavonoid Glycosides of Glinus oppositifolius (L.) Aug. DC. Asian Journal of Chemistry, 34(4), 1003–1008. https://doi.org/10.14233/ajchem.2022.23664
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