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Vol. 31 No. 7 (2019): Vol 31 Issue 7

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Synthesis of New 2-Amino-6-(4-hydroxy-2-oxo-chromen-3-yl)-4-aryl Nicotine Nitrile in Eco-Friendly Media and their Antimicrobials and DPPH Radical Scavenging Activities

https://doi.org/10.14233/ajchem.2019.22062
Aziza Mnasri
Research Laboratory of Environmental Sciences and Technologies (LR16ES09), Higher Institute of Environmental Sciences and Technology, University of Carthage, Hammam-Lif, Tunisia
A. Chakchouk-Mtibaa
Laboratory of Microorganisms and Biomolecules of the Center of Biotechnology of Sfax-Tunisia. Road of Sidi Mansour, Km 6 B.P. 1117, 3018 Sfax, Tunisia
Abdullah Sulaiman Al-Ayed
Department of Chemistry, College of Science and Arts, Qassim University, Al-Rass, Kingdom of Saudi Arabia
Mosbah Jemmali
Department of Chemistry, College of Science and Arts, Qassim University, Al-Rass, Kingdom of Saudi Arabia
L. Mellouli
Laboratory of Microorganisms and Biomolecules of the Center of Biotechnology of Sfax-Tunisia. Road of Sidi Mansour, Km 6 B.P. 1117, 3018 Sfax, Tunisia
Hallouma Bilel
Research Laboratory of Environmental Sciences and Technologies (LR16ES09), Higher Institute of Environmental Sciences and Technology, University of Carthage, Hammam-Lif, Tunisia; Department of Chemistry, College of Science, Jouf University, P.O. Box: 2014, Sakaka, Saudi Arabia
Naceur Hamdi
Research Laboratory of Environmental Sciences and Technologies (LR16ES09), Higher Institute of Environmental Sciences and Technology, University of Carthage, Hammam-Lif, Tunisia; Department of Chemistry, College of Science and Arts, Qassim University, Al-Rass, Kingdom of Saudi Arabia

Corresponding Author(s) : Naceur Hamdi

naceur.hamdi@isste.rnu.tn

Asian Journal of Chemistry, Vol. 31 No. 7 (2019): Vol 31 Issue 7

Abstract

A simple, green, efficient and economical procedure for the synthesis of, 2-amino-6-(4-hydroxy-2-oxo-chromen-3-yl)-4-(aryl) nicotine nitrile (4a-g) by two routes carried in same conditions, have been reported. The new compounds 4a-g were characterized by 1H NMR, 13C NMR, FT-IR and elemental analysis. The synthesized compounds were screened for their antibacterial activities against Gram-positive bacterial strains (Micrococcus luteus LB14110, Staphylococcus aureus ATCC 6538, Listeria monocytogenes ATCC 19117), Gram-negative bacteria (Escherichia coli, Salmonella typhimurium ATCC 14028 and Pseudomonas aeruginosa). The coumarin derivative 4a and 3-acetyl-4-hydroxycouamrin (1) were the most active against two bacteria Staphylococcus aureus ATCC 6538 and Candida albicans respectively. The best minimum inhibitory concentration values were obtained for the compound 4a against Candida albicans (0.0195 g/cm3). In addition, compounds 4a-g were investigated for their antioxidant activities by DPPH (2,2-diphenyl-1-picrylhydrazyl) in which most of them displayed significant antioxidant activities.

Keywords

3-Acetyl-4-hydroxycoumarin Multicomponent reactions Biological activities
Mnasri, A., Chakchouk-Mtibaa, A., Al-Ayed, A. S., Jemmali, M., Mellouli, L., Bilel, H., & Hamdi, N. (2019). Synthesis of New 2-Amino-6-(4-hydroxy-2-oxo-chromen-3-yl)-4-aryl Nicotine Nitrile in Eco-Friendly Media and their Antimicrobials and DPPH Radical Scavenging Activities. Asian Journal of Chemistry, 31(7), 1609–1616. https://doi.org/10.14233/ajchem.2019.22062
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