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Vol. 35 No. 11 (2023): Vol 35 Issue 11, 2023

Copyright (c) 2023 TORATANE MUNEGUMI

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Thermal Synthesis of Polypeptides from N-t-Butyloxycarbonyltripeptide Derivatives without Reactive Side Chains

https://doi.org/10.14233/ajchem.2023.29585
T. MUNEGUMI
Integrated Studies of Education, Naruto University of Education, Naruto, Tokushima 772-8502, Japan Department of Materials Chemistry and Bioengineering, National Institute of Technology, Oyama College, Oyama, Tochigi 323-0806, Japan
https://orcid.org/0000-0003-3754-1874

Corresponding Author(s) : T. MUNEGUMI

toramune@gmail.com

Asian Journal of Chemistry, Vol. 35 No. 11 (2023): Vol 35 Issue 11, 2023

Abstract

The thermal reactions of N-t-butyloxycarbonyl-aspartic acid (Boc-Asp-OH) and some N-t-butyloxycarbonyl derivatives of peptides in which the C-terminal is an aspartic residue as a reactive residue in Boc-Gly-Gly-L-Asp-OH are known. The two carboxy groups at C- zerminal are believed to form an anhydride or give peptide bonds directly. This research reports the thermal reactions of N-Boc-tripeptide derivatives such as Boc-Pro-Pro-Gly-OH, Boc-Pro-Pro-Gly-NH2, Boc-Pro-Pro-Gly-OCH3 and Boc-Ala- Ala-Ala-OH with a carboxy group at C-terminal. Thermal reactions were carried out at a constant temperature near their melting points for 1 to 24 h to afford polypeptides whose average molecular weight reached 2,500 Da.

Keywords

Thermal reaction Sequential peptides N-Boc-tripeptides Proline Alanine
MUNEGUMI, T. (2023). Thermal Synthesis of Polypeptides from N-t-Butyloxycarbonyltripeptide Derivatives without Reactive Side Chains. Asian Journal of Chemistry, 35(11), 2797–2808. https://doi.org/10.14233/ajchem.2023.29585
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