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Vol. 35 No. 7 (2023): Vol 35 Issue 7 (2023)

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Trace Detection Method for Tetramine in Drinking Water by Atmospheric Pressure Gas Chromatography-Mass Spectrometry

https://doi.org/10.14233/ajchem.2023.27905
Hejun Duan
Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Control and Prevention, Beijing, 100013, P.R. China
https://orcid.org/0000-0003-1174-8789
Yixing Feng
Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Control and Prevention, Beijing, 100013, P.R. China
https://orcid.org/0000-0003-0144-1636
Yumin Niu
Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Control and Prevention, Beijing, 100013, P.R. China
https://orcid.org/0009-0005-5622-4884

Corresponding Author(s) : Yumin Niu

15210904641@163.com

Asian Journal of Chemistry, Vol. 35 No. 7 (2023): Vol 35 Issue 7 (2023)

Abstract

This study reports a trace detection method for tetramine in drinking water using atmospheric pressure gas chromatography-tandem mass spectrometry (APGC-MS/MS). After dilution with acetone, the drinking water samples were directly measured using APGC-MS/MS. Separation of tetramine was achieved using a DB-5MS weak polar column (30 m × 0.25 mm, 0.25 μm) and detected with APGC ionization source in positive ion mode. Cone gas and auxiliary flow rates were optimized to 250 L/h and 350 L/h, respectively. Quantitative and qualitative analysis was conducted by monitoring two molecular ions of the target compound (m/z 121.6 and m/z 92.6) under multiple reaction monitoring mode (MRM). The linear relationship between tetramine and its concentration was good in the range of 5-100 ng/L, with a correlation coefficient of 0.9999. The detection limit of the method was 0.3 ng/mL and the quantification limit was 1.0 ng/mL. The recovery of the samples was approximately 80.63% to 86.84%, with an intra-day RSD of 1.2% to 3.5% and an inter-day RSD of 2.9% to 4.9%, which met the requirements for trace detection. This method is simple, fast and highly sensitive and it is suitable for the trace detection of tetramine in drinking water.

Keywords

APGC-MS/MS Water Drinking water Tetramine
Duan, H., Feng, Y., & Niu, Y. (2023). Trace Detection Method for Tetramine in Drinking Water by Atmospheric Pressure Gas Chromatography-Mass Spectrometry. Asian Journal of Chemistry, 35(7), 1692–1696. https://doi.org/10.14233/ajchem.2023.27905
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