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Vol. 32 No. 5 (2020): Vol 32 Issue 5

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Synthesis of Selective Bioactive Pyridylpyridones: in silico Studies and Biological Evaluations

Suresh Ramasamy
Alivira Animal Health Ltd, R & D Center, Visakhapatnam-530019, India; Department of Chemistry, Arignar Anna Government Arts College, Namakkal-637002, India
Singanan Ponnuchamy
Alivira Animal Health Ltd, R & D Center, Visakhapatnam-530019, India
Sivakumar Ponnusamy
Department of Chemistry, Arignar Anna Government Arts College, Namakkal-637002, India

Corresponding Author(s) : Singanan Ponnuchamy

ponnuchamy_85@yahoo.co.in

Asian Journal of Chemistry, Vol. 32 No. 5 (2020): Vol 32 Issue 5

Abstract

Twenty three substituted pyridylpyridones were designed and performed for molecular docking studies against α-amylase enzyme. The top three hit molecules were synthesized and characterized by 1H NMR, 13C NMR, ESI-mass and FT-IR spectroscopic techniques. Experimental biological applications were studied for these compounds. The DFT calculations were executed for the hit compounds. In addition, molecular electrostatic potential mapping was also executed for additional support.

Keywords

Pyridines Anti-diabetic Molecular docking DFT studies Molecular electrostatic map potential
Ramasamy, S., Ponnuchamy, S., & Ponnusamy, S. (2020). Synthesis of Selective Bioactive Pyridylpyridones: in silico Studies and Biological Evaluations. Asian Journal of Chemistry, 32(5), 985–994. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/2413
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