Structural and Antimicrobial Studies of Some Macrocyclic Complexes of Copper(II) of Bioinorganic Relevance

Abstract

Two new macrocyclic complexes have been synthesized by

condensing thiodiacetic acid dihydrazide with 2,6-diacetylpyridine2,6-

pyridinedicarbonyldichloride in presence of copper(II)

ions. The complexes have the formulae Cu[DPTDH](BF₄)₂ and

Cu[DCTDH](BF₄)₂ (where DPTDH = 2,6-diacetylpyridine-N-thiodiacetoylhydrazone

and DCTDH = 2,6-pyridinedicarbonyl-dichloride-

N-thiodiacetoylhydrazone). The synthesized complexes

have been characterized by elemental studies, conductivity measurements,

and spectral (IR and electronic) studies. All these complexes

have been tested in vitro for their antimicrobial activity

against bacteria Staphylococcus arueus (gram positive) and

Escherichia coli (gram negative) and fungi Candida albicans and

Aspergillus niger.