Spectrophotometrioc Determination of Cefixime Trihydrate

Abstract

Two simple, sensitive and selective methods have been developed
for the determination of cefixime in pure and pharmaceutical
preparations. Method A is based on the formation of green coloured
chromogen by ox-idative coupling reaction with 3-methyl-2-
bezothiazolinone hydrazone (MBTH) and ferric chloride having
absorption maximum at 620 nm, whereas method B is based on the
reduction and complex formation with ferric chloride and 1,10-
phenanthroline which exhibit maximum absorption at 510 nm.
These methods obey Beer's law in the concentration range of 1 to
15  μg/mL and 0.2 to 6 μg/mL respectively. The methods are statistically
evaluated for accuracy and precision.