Synthesis, Characterization, Cytotoxicity and Anticomplementary Activity of a Novel Dimethyltin(IV) Cyclobutyl Dicarboxylate Complex of 8-Hydroxyquinaldine

Abstract

The reaction of equimolar quantities of dimethyltin(IV)-cyclobutyl
dicarboxylate (prepared from dimethyltin(IV) dichloride and
silver nitrate followed by addition of dipotassium cyclobutyl dicarboxylate)
and 8-hydroxyquinaldine(L) in ethanol under reflux,
afforded a novel complex of the formula

                               .

The complex was characterized by its elemental analysis and IR,
NMR and mass spectral data. The complex was subjected to
cytotoxic bioassay against one fluid suspension cell line, i.e., P338
and four solid cell lines, i.e., Hep-2, HeLa, L_20B and RD using the
MTT assay technique. It is also tested for its anticomplementary
activity (using a test that detects complement proteins inhibition).
These activities were compared with those of the reference standards,
cisplatin, carboplatin and oxaliplatin as well as with those of
the starting organotin compound against the same cell lines. The
significance of these results is given and discussed.