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Vol. 17 No. 1 (2005): Vol 17 Issue 1

Synthesis and Characterization of New Polyamino-Cholic Acid Dimers

Khaled Q. Shawakfeh
Department of Applied Chemical Science, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan
Naim H. Al-Said
Department of Applied Chemical Science, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan
Ihab Shawish
Department of Applied Chemical Science, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan

Corresponding Author(s) : Khaled Q. Shawakfeh

shawakfa@just.edu.jo

Asian Journal of Chemistry, Vol. 17 No. 1 (2005): Vol 17 Issue 1

Abstract

Cholic acid was selectively protected by trifluoroacetic anhydride, then selectively deprotected at C-3 in order to synthesize 3-keto-diprotected methyl cholate. Dimerization via A-A ring connection was achieved by reductive amination of 3-keto-diprotected methyl cholate with different di and polyamines. Diamines chosen to build SAR were n = 3, 4, 6. In addition, polyamine (spermidine) was chosen to study the effect of increasing the distance between the two sides of dimer in bioactivity. Several dimeric methyl cholate derivatives were synthesized to evaluate their biological activities.

Keywords

Synthesis Characterization Polyamino-cholic acid Dimers
Q. Shawakfeh, K., H. Al-Said, N., & Shawish, I. (2016). Synthesis and Characterization of New Polyamino-Cholic Acid Dimers. Asian Journal of Chemistry, 17(1), 91–97. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/19717
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