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Determination of Trifluoroacetic Acid and Chloride in Celecoxib Drug
Corresponding Author(s) : Meilan Chen
Asian Journal of Chemistry,
Vol. 26 No. 18 (2014): Vol 26 Issue 18
Abstract
A method for the determination of trifluoroacetic acid and chloride in celecoxib drug by valve switching-ion chromatography was developed. Chromatographic separation was performed on an IonPac AS23 column. Mixture of 3.5 mmol/L sodium carbonate and 1.4 mmol/L sodium bicarbonate was used as mobile phase. Since celecoxib is poorly water-soluble (0.007 mg/mL), but extremely soluble in methanol (113.94mg/mL). Ion chromatographic columns are prone to fouling by strongly-retained organic sample components. In our research, column contamination caused by the drug molecule and organic solvent was avoided by using a valve-switching sample preparation method. The linear ranges of the method for the two analytes were 0.10-10 μg/mL and the detection limits (S/N = 3) of trifluoroacetic acid and chloride were 0.06 and 0.006 mg/L, respectively. This method was successfully applied to the determination of trifluoroacetic acid and chloride in real samples. The spiking recoveries of trifluoroacetic acid and chloride were in the range of 90 to 94 %.
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- T.D. Warner, F. Giuliano, I. Vojnovic, A. Bukasa, J.A. Mitchell and J.R. Vane, Proc. Natl. Acad. Sci. USA, 96, 7563 (1999); doi:10.1073/pnas.96.13.7563.
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References
T.D. Warner, F. Giuliano, I. Vojnovic, A. Bukasa, J.A. Mitchell and J.R. Vane, Proc. Natl. Acad. Sci. USA, 96, 7563 (1999); doi:10.1073/pnas.96.13.7563.
G.L. Mengle, R.C. Hubbard, A. Karim, S. Yu, S. Talwalker and P. Isakson, S.G. Geis and B.D. Schwartz, Arthritis Rheum., 40 (Suppl. 9), S93 (1997).
J. Zhang, Y. Zhang, J. Li, J. Hu, P. Ye and Z. Zeng, Water Res., 39, 1331 (2005); doi:10.1016/j.watres.2004.12.043.
O.J. Nielsen, B.F. Scott, C. Spencer, T.J. Wallington and J.C. Ball, Atmos. Environ., 35, 2799 (2001); doi:10.1016/S1352-2310(01)00148-0.
K. Hettiarachchi and S. Ridge, J. Chromatogr. A, 817, 153 (1998); doi:10.1016/S0021-9673(98)00328-8.
M.A. Strege and W.G. Mascher, J. Chromatogr. B: Biomed. Sci. Appl., 697, 255 (1997); doi:10.1016/S0378-4347(96)00493-8.
M.N. El-Attug, B. Lutumba, J. Hoogmartens, E. Adams and A. Van Schepdael, Talanta, 83, 400 (2010); doi:10.1016/j.talanta.2010.09.051.
D.C. Hankins and E.D. Kharasch, J. Chromatogr. B: Biomed. Sci. Appl., 692, 413 (1997); doi:10.1016/S0378-4347(96)00527-0.
N. Simonzadeh, J. Chromatogr. A, 634, 125 (1993); doi:10.1016/0021-9673(93)80320-8.
M. Powell, D. Humphreys, A. Nagle, K. Polowy and M. Scannell, Talanta, 85, 859 (2011); doi:10.1016/j.talanta.2011.04.036.
L. Zhao, X.L. Cao, H.Y. Wang, X. Liu and S.X. Jiang, Chin. Chem. Lett., 19, 219 (2008); doi:10.1016/j.cclet.2007.12.015.