Effect of Acid-Hydrolyzation of Fruits Juice of Apple (Malus domestica), Moushmi (Citrus medica) and Amla (Emblica officinalis) on Solubility of Urinary Stones

Abstract

The object of this study is to analyze the effect of acid-hydrolyzation of juices of common edible fruits i.e., apple (Malus domestica), moushmi (Citrus medica) and amla (Emblica officinalis) on solubility of renal stones of different forms (whole and powdered). Attempts have been made to solubilize the whole stone (bigger- and smaller size) and powdered stone by treating them with acid-hydrolyzed juices of different fruits for 48 and 72 h. This study showed that the solubility of powdered form of urinary stone is much higher than the single whole stone and solubility of single smaller size stone is more than single bigger sized stone. The dissolving property of acid-hydrolyzed juice of amla and apple fruit was comparatively much higher than of moushmi fruit (in descending order). Comparative study showed that all forms and sizes of urinary stones have much higher solubility in acid-hydrolyzed fruits juice than in non-hydrolyzed juice i.e., normal juice of same fruits. This short-term study suggests that acid-hydrolyzed formulation of fruits juice would be helpful in designing of herbal preparation for dissolving, at least partially 'the urinary stones', however, additional studies are needed to evaluate the role of such kinds of acid-hydrolyzed fruit's juice in long-term preventive and therapeutic management of nephrolithiasis.