Investigation of the Formation of Copper(II)-Tryptophane-Aspirin Ternary Complexes
Corresponding Author(s) : Beril Anilanmert
Asian Journal of Chemistry,
Vol. 22 No. 10 (2010): Vol 22 Issue 10
Abstract
Formation constants and the stoichiometric composition of the potentially therapeutic complex of Cu-tryptophane-aspirin were determined potentiometrically, at 25 ºC (± 1) and I = 0.11. The formation constants of binary Cu(II)-aspirin (1:2) complex, on which few and many information exist in literature, were also investigated. Distribution of species was calculated for various pH values. Cu(II)-Tryptophan-aspirin ternary complex formation was confirmed through UV and IR spectrometry and qualitative metal analysis in the precipitates. The stability constants of ternary complexes of Cu(II)-Tryp-ASA were reported, which is important for further studies on this therapeutically important ternary complex, both from the point of synthesis and commenting on its pharmacokinetics.
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