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Vol. 36 No. 11 (2024): Vol 36 Issue 11, 2024

Copyright (c) 2024 sunil Tonde, kalpendra Rajurkar, Nitin Pagar

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis of Lactic Acid via Palladium-Catalyzed Carbonylation of Vinyl Acetate

https://doi.org/10.14233/ajchem.2024.32626
S.S. Tonde
Homogeneous Catalysis Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune-411008, India
https://orcid.org/0009-0007-7902-103X
K.B. Rajurkar
Homogeneous Catalysis Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune-411008, India; Tide Water Oil India Ltd., Mumbai-400079, India
https://orcid.org/0009-0002-3924-0776
N.S. Pagar
Homogeneous Catalysis Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune-411008, India; P.G. Department of Chemistry, Sir Parashurambhau College (Autonomous) (Affiliated to Savitribai Phule Pune University), Pune-411030, India
https://orcid.org/0000-0002-3141-3356

Corresponding Author(s) : N.S. Pagar

nitin.pagar@spcollegepune.ac.in

Asian Journal of Chemistry, Vol. 36 No. 11 (2024): Vol 36 Issue 11, 2024

Abstract

The methoxycarbonylation of vinyl acetate monomer (VAM) was studied with Pd-catalysts at 5.4 MPa CO partial pressure and 373 K. The effects of several acidic and basic ligands in the presence and absence of a promoter were investigated. Using pyridine as ligand in the [PdCl2(PPh3)2]-TsOH catalyst system resulted in 90.01% conversion of VAM and 76.12% selectivity for carbonylation products (methyl-2-acetoxypropionate and methyl lactate). The VAM methoxycarbonylation could be facilitated in a non-polar solvent media and produces methyl-2-acetoxypropionate and methyl lactate, which can be easily converted to lactic acid via hydrolysis.

Keywords

Methoxycarbonylation Vinyl acetate monomer Palladium catalyst Methyl-2-acetoxypropionate Methyl lactate
Tonde, S., Rajurkar, K., & Pagar, N. (2024). Synthesis of Lactic Acid via Palladium-Catalyzed Carbonylation of Vinyl Acetate. Asian Journal of Chemistry, 36(11), 2629–2634. https://doi.org/10.14233/ajchem.2024.32626
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