TY - JOUR AU - Rehman, Sadiq-ur AU - Sherzaman, Saira AU - Aziz Choudhary, Muhammad AU - Aslam Mirza, Muhammad AU - Ansar Yasin, Khawaja PY - 2013/11/12 Y2 - 2024/03/29 TI - Synthesis, Structure Elucidation and Study of Antimicrobial Activity of Stannic(IV) Derivatives JF - Asian Journal of Chemistry JA - ajc VL - 25 IS - 17 SE - Articles DO - 10.14233/ajchem.2013.15158 UR - https://asianpubs.org/index.php/ajchem/article/view/25_18_58 SP - 9688-9692 AB - <p style="text-align: justify;">Six new organotin(IV) compounds with general formulae R<sub>2</sub>Sn(OL)<sub>2</sub> and R<sub>3</sub>SnOL where R = CH<sub>3</sub>, <em>n</em>-C<sub>4</sub>H<sub>9</sub>, C<sub>6</sub>H<sub>5</sub>, OL = 4-oxypiperidine were synthesized by the reaction of R<sub>2</sub>SnCl<sub>2</sub> and R<sub>3</sub>SnCl with stoichiometric amount of 4-hydroxypiperidine in dry ethanol/methanol. These compounds have been characterized by using multinuclear (<sup>1</sup>H, <sup>13</sup>C, <sup>119</sup>Sn) NMR and FT-IR spectroscopy. The spectroscopic results revealed that all the diorganotin(IV) compounds possess trigonal-bipyramidal geometry in solution and a tetrahedral environment around the tin atom in non-coordinating solvents, has been proposed for the triorganotin(IV) compounds. All the synthesized compounds were tested <em>in vitro</em> against a number of microorganisms to assess their biocidal activity. The biological activity of these compounds against various strains of bacteria and fungi has revealed promising activity in comparison with Amphotericin B and miconazole as reference drugs. LD<sub>50</sub> values of some of the tested compounds showed cytotoxicity.</p> ER -