TY - JOUR AU - Kumar Naramsetti, Kiran AU - Alluri, Chandramohan AU - Veera Raghava Sharma, G. PY - 2022/12/27 Y2 - 2024/03/29 TI - Development of Efficient Manufacturing Process for Active Pharmaceutical Ingredient Epalrestat and its Derivatives in Continuous Flow Synthesis JF - Asian Journal of Chemistry JA - ajc VL - 35 IS - 1 SE - Articles DO - 10.14233/ajchem.2023.24008 UR - https://asianpubs.org/index.php/ajchem/article/view/35_1_32 SP - 233-238 AB - <p style="text-align: justify;">An effective method for synthesis of the active pharmaceutical ingredient epalrestat in continuous or tubular flow circumstances with a high yield and a quick reaction time (10 min) has been reported. The reaction conditions for the aldol condensation reaction under tubular continuous flow technology by controlling light-sensitive degradation impurities was optimized. The developed method was more efficient, environmentally benign, time-economic, energy-saving, cost-efficient and also gives a reduction in process mass intensity in comparison with batch process.</p> ER -