TY - JOUR AU - Rishipathak, Dinesh AU - Karanjikar, Chaitrali AU - Udavant, Pavan PY - 2022/12/27 Y2 - 2024/03/28 TI - Microwave Assisted Synthesis and Evaluation of Anticonvulsant Activity of Some 3-(3-(Substituted benzylidine)amino)phenyl-2-phenylquinazolin-4(3H)-ones JF - Asian Journal of Chemistry JA - ajc VL - 35 IS - 1 SE - Articles DO - 10.14233/ajchem.2023.26877 UR - https://asianpubs.org/index.php/ajchem/article/view/35_1_13 SP - 95-98 AB - <p style="text-align: justify;">Herein, the synthesis of 3-(3-(substituted benzylidine)amino)phenyl-2-phenylquinazolin-4(3<em>H</em>)-ones from 3-aminophenyl-2-phenyl-quinazolin-4(3<em>H</em>)-ones is reported. The chemical structures of the synthesized compounds were confirmed by FT-IR, <sup>1</sup>H NMR and <sup>13</sup>C NMR studies. All compounds were evaluated for their anticonvulsant activity against maximal electroshock seizure method. The LD<sub>50</sub> value was found to be 550 mg/Kg and the duration of tonic phase was reduced upto 1.1 s and that of stupor phase was reduced upto 70 s. The structure activity relationship of the compounds revealed that Schiff bases <em>viz.</em> 3-(3-benzylidineamino)phenyl-2-phenylquinazolin-4(3<em>H</em>)-one, 3-(3-(3-chlorobenzylidine)amino)phenyl-2-phenylquinazolin-4(3<em>H</em>)-one, 3-(3-(3-nitrobenzylidine)amino)phenyl-2-phenylquinazolin-4(3<em>H</em>)-one by significantly shorten the tonic and stupor phases of convulsions compared to controls, thus thereby these compounds demonstrated strong anticonvulsant potential.</p> ER -