TY - JOUR AU - Ezhilarasi, M.R. AU - Senthieel Khumar, A.B. AU - Elavarasan, P. PY - 2021/04/16 Y2 - 2024/03/29 TI - Synthesis, in vitro Antimicrobial Evaluation, Molecular Docking Studies and ADME Prediction of Furan-2-yl-Morpholinophenylpyrimidine Derivatives JF - Asian Journal of Chemistry JA - ajc VL - 33 IS - 5 SE - Articles DO - 10.14233/ajchem.2021.23148 UR - https://asianpubs.org/index.php/ajchem/article/view/33_5_21 SP - 1090-1098 AB - <p style="text-align: justify;">A new series of novel 4-(furan-2-yl)-6-(4-morpholinophenyl)pyrimidine-amines (<strong>4a-c</strong>) were synthesized and characterized by elemental analysis and spectral analysis like IR, 1D <sup>1</sup>H &amp; <sup>13</sup>C NMR. The synthesized compounds <strong>4a-c</strong> were evaluated for their biological studies. The zone of inhibitions were examined for synthesized compounds <strong>4a-c</strong> besides the identical set of microbial strains, especially that compound <strong>4a</strong> against <em>S. aureus, S. pyogenes, E. coli</em>, compound <strong>4b</strong> against <em>P. aeruginosa </em>has excellent antibacterial activity. Compound <strong>4c</strong> shows good inhibition against <em>C. albicans</em>. Also <em>in silico </em>molecular docking and ADME predictions were carried for all the compounds. The docking studies were examined by two different proteins like 1UAG protein and 1OQA protein. <em>in silico</em> docking provides of the compounds have good docking score compared with the standard. In the ADME predictions all the compounds were met criteria. The synthesized compounds all of them obeyed the drug-likeness properties.</p> ER -