TY - JOUR AU - B. Harsha, Kachigere AU - V. Kavitha, agirikoppal AU - R. Swaroop, Toreshettahally AU - Rangappa, Shobith AU - S. Rangappa, Kanchugarakoppal PY - 2021/04/16 Y2 - 2024/03/29 TI - A Green Synthesis of 1,5-Benzodiazepines using Reusable-Heterogeneous Silica Sulfuric Acid Catalyst under Solvent-Free Conditions and their Antileukemic Activity JF - Asian Journal of Chemistry JA - ajc VL - 33 IS - 5 SE - Articles DO - 10.14233/ajchem.2021.23103 UR - https://asianpubs.org/index.php/ajchem/article/view/33_5_10 SP - 1006-1012 AB - <p style="text-align: justify;">1,5-Benzodiazepine derivatives are readily assembled from <em>o</em>-phenylene diamine and ketones containg <span style="font-family: Symbol;">&alpha;</span>-hydrogen atoms by means of simple cyclocondensation <em>via</em> <em>sp</em><sup>3</sup> C-H activation promoted by an efficient heterogeneous silica sulfuric acid catalyst. Eco-friendliness, good yields, easy workup, reusable catalyst, short reaction times, high atom economy and solvent-free conditions are the noteworthy features of this protocol. These benzodiazepines are chosen for the evaluation of antiproliferative activity against different leukemia cell lines. Among the investigated compounds, <strong>3g</strong> is the best antiproliferative agent against all the cell lines tested. Also, current preliminary analysis showed that compound <strong>3g</strong> phosphorylates ERK1/2 and induces G1 arrest in K562 cells.</p> ER -