@article{Kumar Naramsetti_Alluri_Veera Raghava Sharma_2022, title={Development of Efficient Manufacturing Process for Active Pharmaceutical Ingredient Epalrestat and its Derivatives in Continuous Flow Synthesis}, volume={35}, url={https://asianpubs.org/index.php/ajchem/article/view/35_1_32}, DOI={10.14233/ajchem.2023.24008}, abstractNote={<p style="text-align: justify;">An effective method for synthesis of the active pharmaceutical ingredient epalrestat in continuous or tubular flow circumstances with a high yield and a quick reaction time (10 min) has been reported. The reaction conditions for the aldol condensation reaction under tubular continuous flow technology by controlling light-sensitive degradation impurities was optimized. The developed method was more efficient, environmentally benign, time-economic, energy-saving, cost-efficient and also gives a reduction in process mass intensity in comparison with batch process.</p>}, number={1}, journal={Asian Journal of Chemistry}, author={Kumar Naramsetti, Kiran and Alluri, Chandramohan and Veera Raghava Sharma, G.}, year={2022}, month={Dec.}, pages={233–238} }