@article{Padmaja_Sumakanth_Shashikala_2022, title={Synthesis, Characterization and Molecular Docking Studies of Novel Mannich Bases of Indole Analogs as Potent Antibacterial and Anticancer Agents}, volume={35}, url={https://asianpubs.org/index.php/ajchem/article/view/35_1_30}, DOI={10.14233/ajchem.2023.24004}, abstractNote={<p style="text-align: justify;">A series of a novel indole analogs (5-substituted-1-methyl/ethyl-3-((5-methyl-1-(morpholino/piperazinmethyl)-1<em>H</em>-pyrazol-3-yl)-imino)indolin-2-one (<strong>5a-l</strong>) were synthesized <em>via</em> Schiff base and Mannich base mechanism. The structures of synthesized compounds were confirmed by IR, <sup>1</sup>H NMR and mass spectral data. The antibacterial activity by was measured by agar diffusion method. Some of the analogs (<strong>5b</strong>, <strong>5c</strong>, <strong>5h</strong>, <strong>5i </strong>and <strong>5j</strong>) showed excellent antibacterial recreation against <em>Staphylococcus aureus, Bacillus subtilis </em>and <em>Escherichia coli, Salmonella paratyphi, Pseudomonas </em>and compounds <strong>5f</strong>, <strong>5g</strong>, <strong>5i </strong>showed good activity against MCF-7 cell line through MTT assay method. The molecular docking studies of novel indole analogs revealed that compound <strong>5i</strong> suggests perfect dock rating of -5.826 with glide binding strength of -38.76 Kcal/mol. Dock results of all the compounds were ranged from -5.826 (compound <strong>5i</strong>) to -2.792 (compound <strong>5d</strong>).</p>}, number={1}, journal={Asian Journal of Chemistry}, author={Padmaja, V. and Sumakanth, M. and Shashikala, P.}, year={2022}, month={Dec.}, pages={217–223} }